Unità di Ricerca: Cardiologia clinica e sperimentale - inrc - Istituto Nazionale Ricerche Cardiovascolari

Unità di Ricerca: Cardiologia clinica e sperimentale

Responsabile/Coordinatore: Prof. Raffaele De Caterina/Prof.ssa Rosalinda Madonna
Sede Universitaria: UO Cardiologia Universitaria 1, Nuovo Ospedale Santa Chiara; Laboratorio di Cardiologia Sperimentale presso Scuola Medica dell’Università di Pisa

Dipartimento: Cardio-Toraco-Vascolare, Azienda Ospedaliera Universitaria Pisana (AOUP); Dipartimento di Patologia Chirurgica, Medica, Molecolare e dell’Area Critica, Università di Pisa

Indirizzo: UO Cardiologia Universitaria 1, Via Paradisa, 56124 Pisa; Laboratorio di Cardiologia Sperimentale, Via Rma Ed 55 56129 Pisa

tel: Segreteria di Dipartimento

e-mail: raffaele.decaterina@unipi.it; rosalinda.madonna@unipi.it

sito web: https://www.ao-pisa.toscana.it/index.php?option=com_content&view=article&id=185:uo-cardiologia-1&catid=103&showall=1&Itemid=113

Linee di ricerca: cardiotossicità indotta da farmaci antineoplastici; ipertensione arteriosa polmonare; terapia cellulare mediante cellule staminali e derivati; meccanismi e nuovi target di trattamento dell’aterosclerosi e dell’insufficienza cardiaca; modelli animali di insufficienza cardiaca e di cardiomiopatia diabetica

Laboratori/strumentazione: manipolazione e utilizzo di animali da laboratorio (ratti, topi); isolamento di cellule muscolari lisce e cellule endoteliali da cordone ombelicale umano, colture cellulari di endotelio, microendotelio, fibroblasti, cellule muscolari lisce, cardiomiociti e cardiomioblasti; saggi spettrofotometrici, cromatografia di affinità; test immunoenzimatici di superficie (EIA), test di adesione cellulare, ELISA; PCR e analisi dei frammenti di restrizione; Dosaggio colorimetrico di nitrato e nitrito. Tecniche di biologia molecolare: estrazione di DNA e RNA, elettroforesi su gel, Southern blotting, Western blotting, Northern Blotting radioattivo e chemiluminescente, PCR con trascrittasi inversa, real-time-PCR, long-PCR, primer design, SDS-PAGE, Immunoblotting, ibridazione in situ; EMSA, Immunocitochimica, Immunoistochimica, immunofluorescenza diretta e indiretta; Citometria a flusso; Microscopia confocale. Cellule staminali embrionali, cellule staminali del midollo osseo, cellule staminali di derivazione adiposa; Ingegneria genetica e terapia genica mediante trasfezione batterica di cellule staminali adulte ed embrionali e linee cellulari somatiche di mammifero; Ingegneria genetica e terapia genica mediante trasfezioni lentivirali di cellule staminali adulte e linee cellulari somatiche di mammifero; lipotrasfezione ed elettroporezione; clonazione e subclonazione; Saggio dell’attività della telomerasi (TRAP); Analisi dei frammenti di restrizione terminale (TRF); Sistema di perfusione Langendorff e preparazione del cuore funzionante; Saggio BRET. modello ratto-topo di ischemia degli arti posteriori; modello ratto-topo di diabete di tipo 1 (iperglicemia indotta da streptozotocina); Ecocardiografia e microiniezione per piccoli e grandi animali, imaging laser doppler (LDI)

Collaborazioni internazionali:

Prof. James T Willerson, Texas Heart Institute, Houston, Texas, US

Prof. Peter Ferdinandy, Semmelweis University, Budapest, Hu

Prof. Montero-Menei, INSERM, Anger, France

Prof. Yong-Jian Geng, UT Medical School in Houston, Texas, US

Prof. AJ Marian, Texas Heart Institute, Houston, Tx

Prof. Dianna Milewicz, UT Medical School in Houston, Texas, US

Elenco ultime pubblicazioni (utlimi 5 anni):

1.Madonna R, Barachini S, Ghelardoni S, Lu L, Shen WF, De Caterina R.

Vasostatins: new molecular targets for atherosclerosis, post-ischaemic

angiogenesis, and arteriogenesis. Cardiovasc Res. 2024 Mar 13;120(2):132-139.

doi: 10.1093/cvr/cvae008. PMID: 38242632.

2: Madonna R, Moscato S, Cufaro MC, Pieragostino D, Mattii L, Del Boccio P,

Ghelardoni S, Zucchi R, De Caterina R. Empagliflozin inhibits excessive

autophagy through the AMPK/GSK3β signalling pathway in diabetic cardiomyopathy.

Cardiovasc Res. 2023 May 22;119(5):1175-1189. doi: 10.1093/cvr/cvad009. PMID:

36627733.

3: Gyöngyösi M, Alcaide P, Asselbergs FW, Brundel BJJM, Camici GG, Martins PDC,

Ferdinandy P, Fontana M, Girao H, Gnecchi M, Gollmann-Tepeköylü C, Kleinbongard

P, Krieg T, Madonna R, Paillard M, Pantazis A, Perrino C, Pesce M, Schiattarella

GG, Sluijter JPG, Steffens S, Tschöpe C, Van Linthout S, Davidson SM. Long COVID

and the cardiovascular system-elucidating causes and cellular mechanisms in

order to develop targeted diagnostic and therapeutic strategies: a joint

Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart

and Myocardial and Pericardial Diseases. Cardiovasc Res. 2023 Mar

31;119(2):336-356. doi: 10.1093/cvr/cvac115. PMID: 35875883; PMCID: PMC9384470.

4.Santovito D, Steffens S, Barachini S, Madonna R. Autophagy, innate immunity,

and cardiac disease. Front Cell Dev Biol. 2023 May 10;11:1149409. doi:

10.3389/fcell.2023.1149409. PMID: 37234771; PMCID: PMC10206260.

5: Madonna R. Unvealing organ-specific endothelial heterogeneity and its

dysfunction. Vascul Pharmacol. 2023 Dec;153:107248. doi:

10.1016/j.vph.2023.107248. Epub 2023 Dec 1. PMID: 38043759.

6: Barachini S, Ghelardoni S, Varga ZV, Mehanna RA, Montt-Guevara MM, Ferdinandy

P, Madonna R. Antineoplastic drugs inducing cardiac and vascular toxicity – An

update. Vascul Pharmacol. 2023 Dec;153:107223. doi: 10.1016/j.vph.2023.107223.

Epub 2023 Sep 8. PMID: 37678516.

7: Barachini S, Ghelardoni S, Madonna R. Vascular Progenitor Cells: From Cancer

to Tissue Repair. J Clin Med. 2023 Mar 20;12(6):2399. doi: 10.3390/jcm12062399.

PMID: 36983398; PMCID: PMC10059009.

8: Manzi G, Mariani MV, Filomena D, Poscia R, Severino P, Iaconelli A, Recchioni

T, Madonna R, Vizza CD, Badagliacca R. Biobanks: The unmet need in heart failure

management. Vascul Pharmacol. 2023 Jun;150:107179. doi:

10.1016/j.vph.2023.107179. Epub 2023 Apr 28. PMID: 37121386.

9: Madonna R. Endothelial heterogeneity and their relevance in cardiac

development and coronary artery disease. Vascul Pharmacol. 2023 Dec;153:107242.

doi: 10.1016/j.vph.2023.107242. Epub 2023 Nov 7. PMID: 37940065.

10: Quarta S, Santarpino G, Carluccio MA, Calabriso N, Maffia M, Siculella L,

Damiano F, Madonna R, Massaro M. Exploring the significance of epicardial

adipose tissue in aortic valve stenosis and left ventricular remodeling:

Unveiling novel therapeutic and prognostic markers of disease. Vascul Pharmacol.

2023 Oct;152:107210. doi: 10.1016/j.vph.2023.107210. Epub 2023 Aug 21. PMID:

37611727.

11: Madonna R, Alberti M, Biondi F, Morganti R, Badagliacca R, Vizza CD, De

Caterina R. Chronic thromboembolic pulmonary disease: Association with exercise-

induced pulmonary hypertension and right ventricle adaptation over time: Chronic

thromboembolic pulmonary disease and exercise pulmonary hypertension. Eur J

Intern Med. 2023 Dec 1:S0953-6205(23)00417-X. doi: 10.1016/j.ejim.2023.11.021.

Epub ahead of print. PMID: 38042668.

12: Di Lisi D, Moreo A, Casavecchia G, Cadeddu Dessalvi C, Bergamini C, Zito C,

Madaudo C, Madonna R, Cameli M, Novo G. Atrial Strain Assessment for the Early

Detection of Cancer Therapy-Related Cardiac Dysfunction in Breast Cancer Women

(The STRANO STUDY: Atrial Strain in Cardio-Oncology). J Clin Med. 2023 Nov

16;12(22):7127. doi: 10.3390/jcm12227127. PMID: 38002739; PMCID: PMC10672006.

13: Steffens S, Nahrendorf M, Madonna R. Immune cells in cardiac homeostasis and

disease: emerging insights from novel technologies. Eur Heart J. 2022 Apr

19;43(16):1533-1541. doi: 10.1093/eurheartj/ehab842. PMID: 34897403; PMCID:

PMC9020986.

14: Khachigian LM, Black BL, Ferdinandy P, De Caterina R, Madonna R, Geng YJ.

Transcriptional regulation of vascular smooth muscle cell proliferation,

differentiation and senescence: Novel targets for therapy. Vascul Pharmacol.

2022 Oct;146:107091. doi: 10.1016/j.vph.2022.107091. Epub 2022 Jul 25. PMID:

35896140.

15: Madonna R. Exploring Enhanced Cell-Based Therapy for Ischemic Heart Disease

and Heart Failure. J Clin Med. 2022 Jul 1;11(13):3837. doi: 10.3390/jcm11133837.

PMID: 35807122; PMCID: PMC9267183.

16: Evans PC, Davidson SM, Wojta J, Bäck M, Bollini S, Brittan M, Catapano AL,

Chaudhry B, Cluitmans M, Gnecchi M, Guzik TJ, Hoefer I, Madonna R, Monteiro JP,

Morawietz H, Osto E, Padró T, Sluimer JC, Tocchetti CG, Van der Heiden K,

Vilahur G, Waltenberger J, Weber C. From novel discovery tools and biomarkers to

precision medicine-basic cardiovascular science highlights of 2021/22.

Cardiovasc Res. 2022 Oct 21;118(13):2754-2767. doi: 10.1093/cvr/cvac114. PMID:

35899362; PMCID: PMC9384606.

17: Madonna R. Pulmonary Arterial Hypertension in Genetic and Comorbid Settings:

A Step Forward for Precision Medicine. J Clin Med. 2022 Nov 10;11(22):6671. doi:

10.3390/jcm11226671. PMID: 36431147; PMCID: PMC9693587.

18: Madonna R. Angiocrine endothelium: From physiology to atherosclerosis and

cardiac repair. Vascul Pharmacol. 2022 Jun;144:106993. doi:

10.1016/j.vph.2022.106993. Epub 2022 Apr 9. PMID: 35413438.

19: Mazzola M, Madonna R, Badagliacca R, Caterina R. Porto-pulmonary arterial

hypertension: Translation of pathophysiological concepts to the bedside. Vascul

Pharmacol. 2022 Aug;145:107022. doi: 10.1016/j.vph.2022.107022. Epub 2022 Jun

20. PMID: 35738494.

20: Cocco N, Madonna R, Cammalleri V, Cocco G, De Stefano D, Ricciardi D,

Grigioni F, Ussia GP. Percutaneous treatment of a CTO in an anomalous right

coronary artery: A rupture paved the way for new insights. Front Cardiovasc Med.

2022 Jul 29;9:916616. doi: 10.3389/fcvm.2022.916616. PMID: 35966553; PMCID:

PMC9372292.

21: van der Velden J, Asselbergs FW, Bakkers J, Batkai S, Bertrand L, Bezzina CR,

Bot I, Brundel BJJM, Carrier L, Chamuleau S, Ciccarelli M, Dawson D, Davidson

SM, Dendorfer A, Duncker DJ, Eschenhagen T, Fabritz L, Falcão-Pires I,

Ferdinandy P, Giacca M, Girao H, Gollmann-Tepeköylü C, Gyongyosi M, Guzik TJ,

Hamdani N, Heymans S, Hilfiker A, Hilfiker-Kleiner D, Hoekstra AG, Hulot JS,

Kuster DWD, van Laake LW, Lecour S, Leiner T, Linke WA, Lumens J, Lutgens E,

Madonna R, Maegdefessel L, Mayr M, van der Meer P, Passier R, Perbellini F,

Perrino C, Pesce M, Priori S, Remme CA, Rosenhahn B, Schotten U, Schulz R,

Sipido KR, Sluijter JPG, van Steenbeek F, Steffens S, Terracciano CM, Tocchetti

CG, Vlasman P, Yeung KK, Zacchigna S, Zwaagman D, Thum T. Animal models and

animal-free innovations for cardiovascular research: current status and routes

to be explored. Consensus document of the ESC Working Group on Myocardial

Function and the ESC Working Group on Cellular Biology of the Heart. Cardiovasc

Res. 2022 Dec 9;118(15):3016-3051. doi: 10.1093/cvr/cvab370. PMID: 34999816;

PMCID: PMC9732557.

22: Madonna R, Barachini S, Moscato S, Ippolito C, Mattii L, Lenzi C, Balistreri

CR, Zucchi R, De Caterina R. Sodium-glucose cotransporter type 2 inhibitors

prevent ponatinib-induced endothelial senescence and disfunction: A potential

rescue strategy. Vascul Pharmacol. 2022 Feb;142:106949. doi:

10.1016/j.vph.2021.106949. Epub 2021 Nov 26. PMID: 34843980.

23: Madonna R, Fabiani S, Morganti R, Forniti A, Biondi F, Ridolfi L, Iapoce R,

Menichetti F, De Caterina R. Exercise-Induced Pulmonary Hypertension Is

Associated with High Cardiovascular Risk in Patients with HIV. J Clin Med. 2022

Apr 27;11(9):2447. doi: 10.3390/jcm11092447. PMID: 35566573; PMCID: PMC9100247.

24: Pugliese NR, Mazzola M, Madonna R, Gargani L, De Biase N, Dini FL, Taddei S,

De Caterina R, Masi S. Exercise-induced pulmonary hypertension in HFpEF and

HFrEF: Different pathophysiologic mechanism behind similar functional

impairment. Vascul Pharmacol. 2022 Jun;144:106978. doi:

10.1016/j.vph.2022.106978. Epub 2022 Mar 15. PMID: 35301117.

25: Manzi G, Papa S, Mariani MV, Scoccia G, Filomena D, Malerba C, Adamo FI,

Caputo A, De Lazzari C, De Lazzari B, Cedrone N, Madonna R, Recchioni T, Serino

G, Vizza CD, Badagliacca R. Telehealth: A winning weapon to face the COVID-19

outbreak for patients with pulmonary arterial hypertension. Vascul Pharmacol.

2022 Aug;145:107024. doi: 10.1016/j.vph.2022.107024. Epub 2022 Jun 16. PMID:

35716991; PMCID: PMC9212864.

26: Lecour S, Du Pré BC, Bøtker HE, Brundel BJJM, Daiber A, Davidson SM,

Ferdinandy P, Girao H, Gollmann-Tepeköylü C, Gyöngyösi M, Hausenloy DJ, Madonna

R, Marber M, Perrino C, Pesce M, Schulz R, Sluijter JPG, Steffens S, Van

Linthout S, Young ME, Van Laake LW. Circadian rhythms in ischaemic heart

disease: key aspects for preclinical and translational research: position paper

of the ESC working group on cellular biology of the heart. Cardiovasc Res. 2022

Sep 20;118(12):2566-2581. doi: 10.1093/cvr/cvab293. PMID: 34505881.

27: Madonna R, Barachini S, Ghelardoni S, Lu L, Shen WF, De Caterina R.

Vasostatins: new molecular targets for atherosclerosis, post-ischaemic

angiogenesis, and arteriogenesis. Cardiovasc Res. 2024 Mar 13;120(2):132-139.

doi: 10.1093/cvr/cvae008. PMID: 38242632.

28: Madonna R, Pieragostino D, Cufaro MC, Del Boccio P, Pucci A, Mattii L, Doria

V, Cadeddu Dessalvi C, Zucchi R, Mercuro G, De Caterina R. Sex-related

differential susceptibility to ponatinib cardiotoxicity and differential

modulation of the Notch1 signalling pathway in a murine model. J Cell Mol Med.

2022 Mar;26(5):1380-1391. doi: 10.1111/jcmm.17008. Epub 2022 Feb 5. PMID:

35122387; PMCID: PMC8899159.

29: Badagliacca R, Papa S, D’Alto M, Ghio S, Agostoni P, Ameri P, Argiento P,

Brunetti ND, Casamassima V, Casu G, Cedrone N, Confalonieri M, Corda M, Correale

M, D’Agostino C, De Michele L, Famoso G, Galgano G, Greco A, Lombardi CM, Manzi

G, Madonna R, Mercurio V, Mulè M, Paciocco G, Romaniello A, Romeo E, Scelsi L,

Serra W, Stolfo D, Toma M, Vatrano M, Vitulo P, Vizza CD; italian Pulmonary

Hypertension NETwork (iPHNET). The paradox of pulmonary arterial hypertension in

Italy in the COVID-19 era: is risk of disease progression around the corner? Eur

Respir J. 2022 Oct 6;60(4):2102276. doi: 10.1183/13993003.02276-2021. PMID:

35301247; PMCID: PMC9535117.

30: Madonna R, Ridolfi L, Morganti R, Biondi F, Fabiani S, Forniti A, Iapoce R,

De Caterina R. Impact of Exercise-Induced Pulmonary Hypertension on Right

Ventricular Function and on Worsening of Cardiovascular Risk in HIV Patients. J

Clin Med. 2022 Dec 10;11(24):7349. doi: 10.3390/jcm11247349. PMID: 36555965;

PMCID: PMC9781486.

31: Madonna R. Vascular rejuvenation: a new therapeutic target? Eur Heart J. 2021

Nov 7;42(42):4370-4372. doi: 10.1093/eurheartj/ehab587. PMID: 34595518.

32: Evans PC, Davidson SM, Wojta J, Bäck M, Bollini S, Brittan M, Catapano AL,

Chaudhry B, Cluitmans M, Gnecchi M, Guzik TJ, Hoefer I, Madonna R, Monteiro JP,

Morawietz H, Osto E, Padró T, Sluimer JC, Tocchetti CG, Van der Heiden K,

Vilahur G, Waltenberger J, Weber C. From novel discovery tools and biomarkers to

precision medicine-basic cardiovascular science highlights of 2021/22.

Cardiovasc Res. 2022 Oct 21;118(13):2754-2767. doi: 10.1093/cvr/cvac114. PMID:

35899362; PMCID: PMC9384606.

33: Lionetti V, Bollini S, Coppini R, Gerbino A, Ghigo A, Iaccarino G, Madonna R,

Mangiacapra F, Miragoli M, Moccia F, Munaron L, Pagliaro P, Parenti A, Pasqua T,

Penna C, Quaini F, Rocca C, Samaja M, Sartiani L, Soda T, Tocchetti CG, Angelone

T. Understanding the heart-brain axis response in COVID-19 patients: A

suggestive perspective for therapeutic development. Pharmacol Res. 2021

Jun;168:105581. doi: 10.1016/j.phrs.2021.105581. Epub 2021 Mar 26. PMID:

33781873; PMCID: PMC7997688.

34: Marian AJ, Asatryan B, Bolli R, Cheedipudi SM, Dhalla NS, Finkel T,

Frangogiannis NG, Gurha P, Belmonte JCI, Hare JM, Hong K, Kirshenbaum LA, Lee

RT, Leesar MA, Libby P, Madonna R, Nagueh SF, Roberts R, Rosenzweig A, Rouhi L,

Sadoshima J, Sussman MA, Taffet GE, Tanaka H, Torella D, Wang Y, Wang DW.

Editors’ Preamble to <i>The Journal of Cardiovascular Aging</i>. J Cardiovasc

Aging. 2021;1:1. doi: 10.20517/jca.2021.01. Epub 2021 Apr 27. PMID: 34327514;

PMCID: PMC8318349.

35: Geng YJ, Madonna R, Hermida RC, Smolensky MH. Pharmacogenomics and circadian

rhythms as mediators of cardiovascular drug-drug interactions. Curr Res

Pharmacol Drug Discov. 2021 May 6;2:100025. doi: 10.1016/j.crphar.2021.100025.

Erratum in: Curr Res Pharmacol Drug Discov. 2021 Jun 24;2:100032. PMID:

34909660; PMCID: PMC8663962.

36: Balistreri CR, Madonna R, Ferdinandy P. Is it the time of seno-therapeutics

application in cardiovascular pathological conditions related to ageing? Curr

Res Pharmacol Drug Discov. 2021 May 13;2:100027. doi:

10.1016/j.crphar.2021.100027. Erratum in: Curr Res Pharmacol Drug Discov. 2021

Jun 24;2:100032. PMID: 34909661; PMCID: PMC8663954.

37: Madonna R. Exploring the mechanisms of action of gliflozines in heart failure

and possible implications in pulmonary hypertension. Vascul Pharmacol. 2021

Jun;138:106839. doi: 10.1016/j.vph.2021.106839. Epub 2021 Jan 30. PMID:

33524548.

38: Perrino C, Ferdinandy P, Bøtker HE, Brundel BJJM, Collins P, Davidson SM, den

Ruijter HM, Engel FB, Gerdts E, Girao H, Gyöngyösi M, Hausenloy DJ, Lecour S,

Madonna R, Marber M, Murphy E, Pesce M, Regitz-Zagrosek V, Sluijter JPG,

Steffens S, Gollmann-Tepeköylü C, Van Laake LW, Van Linthout S, Schulz R,

Ytrehus K. Improving translational research in sex-specific effects of

comorbidities and risk factors in ischaemic heart disease and cardioprotection:

position paper and recommendations of the ESC Working Group on Cellular Biology

of the Heart. Cardiovasc Res. 2021 Jan 21;117(2):367-385. doi:

10.1093/cvr/cvaa155. PMID: 32484892; PMCID: PMC7820844.

39: Madonna R, Guarnieri S, Kovácsházi C, Görbe A, Giricz Z, Geng YJ, Mariggiò

MA, Ferdinandy P, De Caterina R. Telomerase/myocardin expressing mesenchymal

cells induce survival and cardiovascular markers in cardiac stromal cells

undergoing ischaemia/reperfusion. J Cell Mol Med. 2021 Jun;25(12):5381-5390.

doi: 10.1111/jcmm.16549. Epub 2021 May 5. PMID: 33949765; PMCID: PMC8184669.

40: Madonna R, Barachini S, Moscato S, Ippolito C, Mattii L, Lenzi C, Balistreri

CR, Zucchi R, De Caterina R. Sodium-glucose cotransporter type 2 inhibitors

prevent ponatinib-induced endothelial senescence and disfunction: A potential

rescue strategy. Vascul Pharmacol. 2022 Feb;142:106949. doi:

10.1016/j.vph.2021.106949. Epub 2021 Nov 26. PMID: 34843980.

41: Madonna R, Fabiani S, Morganti R, Forniti A, Mazzola M, Menichetti F, De

Caterina R. Exercise-induced pulmonary hypertension in HIV patients: Association

with poor clinical and immunological status. Vascul Pharmacol. 2021

Aug;139:106888. doi: 10.1016/j.vph.2021.106888. Epub 2021 Jun 26. PMID:

34182165.

42: Madonna R. Multi-Target Drugs for Blood Cancer in the Elderly: Implications

of Damage and Repair in the Cardiovascular Toxicity. Front Physiol. 2021 Dec

7;12:792751. doi: 10.3389/fphys.2021.792751. PMID: 34950060; PMCID: PMC8688949.

43: Madonna R, Moscato S, Polizzi E, Pieragostino D, Cufaro MC, Del Boccio P,

Bianchi F, De Caterina R, Mattii L. Connexin 43 and Connexin 26 Involvement in

the Ponatinib-Induced Cardiomyopathy: Sex-Related Differences in a Murine Model.

Int J Mol Sci. 2021 May 28;22(11):5815. doi: 10.3390/ijms22115815. PMID:

34071707; PMCID: PMC8199144.

44: Pesce M, Agostoni P, Bøtker HE, Brundel B, Davidson SM, Caterina R,

Ferdinandy P, Girao H, Gyöngyösi M, Hulot JS, Lecour S, Perrino C, Schulz R,

Sluijter JP, Steffens S, Tancevski I, Gollmann-Tepeköylü C, Tschöpe C, Linthout

SV, Madonna R. COVID-19-related cardiac complications from clinical evidences to

basic mechanisms: opinion paper of the ESC Working Group on Cellular Biology of

the Heart. Cardiovasc Res. 2021 Aug 29;117(10):2148-2160. doi:

10.1093/cvr/cvab201. PMID: 34117887.

45: Bulluck H, Paradies V, Barbato E, Baumbach A, Bøtker HE, Capodanno D, De

Caterina R, Cavallini C, Davidson SM, Feldman DN, Ferdinandy P, Gili S,

Gyöngyösi M, Kunadian V, Ooi SY, Madonna R, Marber M, Mehran R, Ndrepepa G,

Perrino C, Schüpke S, Silvain J, Sluijter JPG, Tarantini G, Toth GG, Van Laake

LW, von Birgelen C, Zeitouni M, Jaffe AS, Thygesen K, Hausenloy DJ.

Prognostically relevant periprocedural myocardial injury and infarction

associated with percutaneous coronary interventions: a Consensus Document of the

ESC Working Group on Cellular Biology of the Heart and European Association of

Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. 2021 Jul

15;42(27):2630-2642. doi: 10.1093/eurheartj/ehab271. PMID: 34059914; PMCID:

PMC8282317.

46: Zito C, Manganaro R, Cusmà Piccione M, Madonna R, Monte I, Novo G, Mercurio

V, Longobardo L, Cadeddu Dessalvi C, Deidda M, Pagliaro P, Spallarossa P,

Costantino R, Santarpia M, Altavilla G, Carerj S, Tocchetti CG. Anthracyclines

and regional myocardial damage in breast cancer patients. A multicentre study

from the Working Group on Drug Cardiotoxicity and Cardioprotection, Italian

Society of Cardiology (SIC). Eur Heart J Cardiovasc Imaging. 2021 Mar

22;22(4):406-415. doi: 10.1093/ehjci/jeaa339. PMID: 33432333.

47: Grigorian-Shamagian L, Sanz-Ruiz R, Climent A, Badimon L, Barile L, Bolli R,

Chamuleau S, Grobbee DE, Janssens S, Kastrup J, Kragten-Tabatabaie L, Madonna R,

Mathur A, Menasché P, Pompilio G, Prosper F, Sena E, Smart N, Zimmermann WH,

Fernández-Avilés F. Insights into therapeutic products, preclinical research

models, and clinical trials in cardiac regenerative and reparative medicine:

where are we now and the way ahead. Current opinion paper of the ESC Working

Group on Cardiovascular Regenerative and Reparative Medicine. Cardiovasc Res.

2021 May 25;117(6):1428-1433. doi: 10.1093/cvr/cvaa337. PMID: 33258961.

48: Gyöngyösi M, Alcaide P, Asselbergs FW, Brundel BJJM, Camici GG, Martins PDC,