Telecardiologia & Applicazioni Cliniche di Modelli Numerici di Sistemi Biologici (Claudio De Lazzari)

Unità di Ricerca: Telecardiologia & Applicazioni Cliniche di Modelli Numerici di Sistemi Biologici

Responsabile/Coordinatore: Prof. Claudio De Lazzari

Sede CNR: Dipartimento di Scienze Biomediche, Istituto di Fisiologia Clinica, Sezione di Roma.

Indirizzo: Via   Via Palestro, 32 (00185 Roma)

tel: (+39) 06 4993 6299

e-mail:  claudio.delazzari@cnr.it

sito web:  http://cardiosim.dsb.cnr.it/

 Linee di ricerca:

RESPIRATORY SYSTEM  MODELING: of heart-lung interaction during mechanical ventilation and mechanical circulatory assistance. Thoracic artificial Lung (TAL) and Extracorporeal Membrane Oxygenation (ECMO): R&D on 0-D numerical and hybrid (numerical/hydraulic) models. Clinical data validation.

CARDIAC RESYNCHRONIZATION THERAPY (CRT): R&D on a numerical model of the cardiovascular system enables to reproduce severe and moderate heart failure (HF) and the effects of cardiac resynchronization therapy (CRT) using a biventricular pacemaker. The software will be useful for cardiologist to optimize pacemaker temporization.

VENTRICULAR ASSIST DEVICES: R&D on a new numerical models of the ventricular assis devices (e.g. IABP, ECMO, Impella pump, Tandem Hearth, ProtekDuo, HeartMate 3 LVA, ECPELLA, etc.). Clinical data validation. R&D on Ventricular Assist Devices (VADs) protocols for the management of pulsatile and continuous flow VADs: “in vitro” test for pulsatile/continuous flow pumps.

TELECARDIOLOGY: Telecardiology pilot study designed for students in order to prevent cases of sudden cardiac death (SCD). R&D on wearable device enables to acquire and send in-real time several haemodynamic parameters and electrical signals. The device is equipped with a software enabling to predict (using numerical models) starting from measured data, haemodynamic and energetic parameter values that cannot be directly measured.

NUMERICAL STEM CELL THERAPY: R&D on a numerical model to analyze nutrient transport and cardiac stem cell proliferation in an ischemic area of the heart. Simulation of stem cell therapy for different types of HF. In silico and in vitro study.

E-LEARNING AND MEDICAL SIMULATION TRAINING (MST): courses for medical clinical and biomedical engineer students and for physicians and other medical professionals (e.g. Cardilogists, Cardiac Surgeons, Anesthesiologists, Family medicine physicians, Clinical perfusionists nurses, etc.).

MST courses at Geomedi University-Medical Faculty (Georgia) in cooperation with Department of Cardiovascular, Respiratory, Anaesthetic and Geriatric Sciences, Sapienza University, (Rome – Italy) and with Uniklinik RWTH (Aachen Clinics) Institute of Physiology (Aachen University – Germany).

MST courses at Department of Cardiovascular, Respiratory, Anaesthetic and Geriatric Sciences, Sapienza University, (Rome – Italy). Higher Education Course called “Il Paziente “virtuale” per la Formazione in Cardiologia”.

MST courses at RWTH Aachen University in the context of “Master’s of Science program in Biomedical Engineering”.

Laboratori/strumentazione:

Informatica: 4 Stazioni di lavoro complete di Computer, Stampanti, Scanner. WiFi per collegare devices.

Elettronica: Oscilloscopio analogico; Oscilloscopio digitale; Tester; Amplificatori di potenza; Alimentatori; Generatore di funzione; Serie completa di resistenze, condensatori, transistor, led, circuiti integrati; Capacimetro; Serie completa di manuali di Elettronica/Elettrotecnica; Termometro digitale; Cavetteria; Saldatori termostatati; Motori passo-passo; Banco lavoro; Pinze becco piatto; Pinze punta curva; Trapano da circuito stampato.

Meccanica: Compressore; Piegatrice; Banco lavoro; Taglierina; Trapano a colonna; Chiavi inglesi; Brugole; Set cacciaviti a taglio e croce; Martelli; Pinze; Tenaglie; Punte da trapano per ferro.

Collaborazioni internazionali:

Massachusetts General Hospital Division of Vascular and Endovascular Surgery (USA); Laboratory for Extracorporeal Circulation Research (ECCLab) – Aachen University (DE); Medical Faculty of Geomedi University (Georgia); Faculty of Software and Information Science, Iwate Prefectural University, (Japan); Université du Québec à Montréal (Canada); Golden Jubilee National Hospital, Clydebank-Glasgow (UK); Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust (UK); School of Engineering, Ulster University—Belfast, United Kingdom of Great Britain and Northern Ireland (UK); Department of Biomedical Engineering, University of Strathclyde, Glasgow (UK); Whiting School of Engineering Johns Hopkins University Baltimore (USA)

Elenco ultime pubblicazioni:

  1. 2023 De Lazzari, M. Capoccia, R. Badagliacca and C. De Lazzari. Modelling and Simulation of the Combined Use of IABP and Impella as a Rescue Procedure in Cardiogenic Shock: An Alternative for Non-Transplant Centres? Bioengineering, 10(12), 1434, 1-12.

(https://doi.org/10.3390/bioengineering10121434).

  1. 2023 Alkan, B. De Lazzari, M. Capoccia, C. De Lazzari, S. Bozkurt. Computational Evaluation of IABP, Impella 2.5, TandemHeart and Combined IABP and Impella 2.5 Support in Cardiogenic Shock. Mathematics, 11(16), 3606, 1-17 (https://doi.org/10.3390/math11163606).
  1. 2023 De Lazzari, M. Capoccia, R. Badagliacca, S. Bozkurt and C. De Lazzari. IABP Versus Impella Support in Cardiogenic Shock: “In Silico” Study. Journal of Cardiovascular Development and Disease, 10(4), 140, 1-15 (https://doi.org/10.3390/jcdd10040140).
  1. 2023 De Lazzari, M. Capoccia, N.J. Cheshire, U.P. Rosendahl, R. Badagliacca, and C. De Lazzari. Evaluation of Different Cannulation Strategies for Aortic Arch Surgery Using a Cardiovascular Numerical Simulator. Bioengineering, 10, 60, 1-24. (https://doi.org/10.3390/bioengineering10010060).
  1. 2022 De Lazzari, R. Badagliacca, D. Filomena, S. Papa, C.D. Vizza, M. Capoccia and C. De Lazzari. CARDIOSIM©: The First Italian Software Platform for Simulation of the Cardiovascular System and Mechanical Circulatory and Ventilatory Support. Bioengineering, 9(8), 383.

(https://doi.org/10.3390/bioengineering9080383).

  1. 2022 Manzi, S. Papa, M.V. Mariani, G. Scoccia, D. Filomena, C. Malerba, F. Adamo, A. Caputo, C. De Lazzari, B. De Lazzari, N. Cedrone, R. Madonna, T. Recchioni, G. Serino, C.D. Vizza, R. Badagliacca. Telehealth: A winning weapon to face the COVID-19 outbreak for patients with pulmonary arterial hypertension. Vascular Pharmacology, 145, (https://doi.org/10.1016/j.vph.2022.107024).
  1. 2022 De Lazzari, A. Iacovoni, M. Capoccia, S. Papa, R. Badagliacca, D. Filomena and C. De Lazzari. Ventricular and Atrial Pressure-Volume Loops: Analysis of the Effects Induced by Right Centrifugal Pump Assistance. Bioengineering, 9(5), 181, (https://doi.org/10.3390/bioengineering9050181).
  1. 2021 Manzi, C. Miotti, M.V. Mariani, S. Papa, F. Luongo, G. Scoccia, B. De Lazzari, C. De Lazzari, R.L. Benza, F. Fedele, C.D. Vizza, R. Badagliacca. Computational Simulator Models and Invasive Hemodynamic Monitoring as Tools for Precision Medicine in Pulmonary Arterial Hypertension. Journal of Clinical Medicine, 11(1), 82. (https://doi.org/10.3390/jcm11010082).
  1. 2021 Capoccia, C. De Lazzari, D.M. Pisanelli, B. De Lazzari. Telemedicine and telehealth: an Italian and UK perspective. Current Issues of Medicine and Management (ISSN: 1512-4169), vol. 2(22), 4-17.

(https://doi.org/10.52340/mid.2021.637).

  1. 2021 Mancone, V. Maestrini, A. Fusto, F. Adamo, P. Scarparo, A. D’Ambrosi, A. Cinque, M.C. Gatto, N. Salvi, G. Agnes, M. Pucci, L.I. Birtolo, L. Marruncheddu, I. Genuini, C. De Lazzari, et al. ECG evaluation in 11 949 Italian teenager’s results of screening in secondary school. Journal of Cardiovascular Medicine: September 24, 2021. (https://doi.org/10.2459/jcm.0000000000001259).
  1. 2021 De Lazzari, A. Iacovoni, K. Mottaghy, M. Capoccia, R. Badagliacca, C.D. Vizza, C. De Lazzari. ECMO Assistance During Mechanical Ventilation: Effects Induced on Energetic and Haemodynamic Variables. Computer Methods and Programs in Biomedicine, vol. 202; 1-13.

(https://doi.org/10.1016/j.cmpb.202.106003).

  1. 2020 De Lazzari, B. De Lazzari, A. Iacovoni, S. Marconi, S. Papa, M. Capoccia, R. Badagliacca, C.D. Vizza. Intra-Aortic Balloon Counterpulsation Timing: A New Numerical Model for Programming and Training in the Clinical Environment. Computer Methods and Programs in Biomedicine, vol. 194; 1-9.

(https://doi.org/10.1016/j.cmpb.2020.105537).

  1. 2019 De Lazzari, S. Marconi, M. Capoccia, S. Papa, R. Badagliacca, C.D. Vizza. A 0-D Model to Predict the Relationship between Resistance and Compliance in Pulmonary Arterial Hypertension. Proceedings of the 31TH European Modeling and Simulation Symposium. (ISBN 978-88-85741-25-6). Edit by Affenzeller, Bruzzone, Longo, Piera 23-28
  1. 2019 De Lazzari, M. Capoccia, S. Marconi. How can LVAD support influence ventricular energetics parameters in advanced heart failure patients? A retrospective study .Computer Methods and Programs in Biomedicine, 172, 117-126. (https://doi.org/10.1016%2Fj.cmpb.2019.02.012).
  1. 2018 Marconi, C. De Lazzari. A Lumped Parameter Model of Airway/Lung Mechanics. Proceedings of the 30TH European Modeling and Simulation Symposium. (ISBN 978-88-85741-03-4). Edit by Affenzeller, Bruzzone, Jiménez, Longo, Merkuryev and Piera. 54-58.
  1. 2018 Marconi, M. Ledda, A.M. Bersani, I. Giorgio, A. Lisi, E. Bersani, D. Andreucci, I. Genuini, D.M. Pisanelli, C. De Lazzari. Multidisciplinary Approach to Myocardial Regeneration: In Vitro and In Silico Studies of Stem Cells Behaviour. New trends in software methodologies, tools and techniques. Proceedings of SoMeT 2018. (ISBN 978-1-61499-899-0). Edit by H. Fujita, E. Herrera-Viedma IOS Press (Amsterdam), vol. 303; 121 – 134. doi: 10.3233/978-1-61499-900-3-12.
  1. 2018M. Pisanelli, C. De Lazzari, I. Genuini. An Ontology of Mechanical Circulatory Assist Devices Aimed at the Realization of a Decision Support System. New trends in software methodologies, tools and techniques. Proceedings of SoMeT 2018. (ISBN 978-1-61499-899-0). Edit by H. Fujita, E. Herrera-Viedma IOS Press (Amsterdam), vol. 303; 507 – 514. doi: 10.3233/978-1-61499-900-3-507.
  1. 2018 Capoccia, S. Marconi, and C. De Lazzari. Decision-making in advanced heart failure patients requiring LVAD insertion: Can preoperative simulation become the way forward? A case study. Journal of Biomedical Engineering and Informatics, 4(2); 8-20. (https://doi.org/10.5430/jbei.v4n2p8).
  1. 2018 Capoccia, S. Marconi, C. De Lazzari. A Simulation Approach to Guide Therapeutic Intervention in Advanced Heart Failure. PROCEEDINGS of BioMedEng18 Conference (ISBN 978-1-9996465-0-9),87. https://www.biomedeng18.com/conference-proceedings.
  1. 2018 Ledda, E. D’Emilia, M.G. Lolli, R. Marchese, C. De Lazzari and A. Lisi. Non-Ionizing Radiation for Cardiac Human Amniotic Mesenchymal Stromal Cell Commitment: A Physical Strategy in Regenerative Medicine. Int. J. Mol. Sci. 19(8), 2324. (https://doi.org/10.3390/ijms19082324).
  1. 2018 Marconi, C. Cappelli, M. Capoccia, D.M. Pisanelli, I. Genuini, and C. De Lazzari. A New Numerical Model of the Intra-aortic Balloon Pump as a Tool for Clinical Simulation and Outcome Prediction. In L. Lhotska et al. (eds.) World Congress on Medical Physics and Biomedical Engineering, Prague 3-8 June 2018. IFMBE Proceedings (68/3), 795-799. doi: 10.1007/978-981-10-9023-3_144.
  1. 2018 Capoccia, S. Marconi, S.A. Singh, D.M. Pisanelli and C. De Lazzari. Simulation as a preoperative planning approach in advanced heart failure patients. A retrospective clinical analysis. BioMedical Engineering OnLine, 17 (1), 52. doi: 10.1186/s12938-018-0491-7.
 

BOOKS and CHAPTERS

  • 2023 De Lazzari, M. Capoccia and C. De Lazzari. CARDIOSIM© Cardiovascular Software Simulator for the Study of ECMO Support and Mechanical Ventilation Interaction. In: HORIZONS in WORLD CARDIOVASCULAR RESEARCH. E.H. Bennington Ed. New York:  Nova Science Publisher. (ISBN: 979-8-88697-473-7 (eBooK) ISSN: 2157-6130), 24, 173-205.
  • 2019 Capoccia, C. De Lazzari. CONCEPTS, MATHEMATICAL MODELLING AND APPLICATIONS IN HEART FAILURE. M. Capoccia and C. De Lazzari Eds. New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1).
  • 2019 Capoccia and C. De Lazzari. Mechanical Circulatory Assist Devices: Overview. In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds.  New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 1-22.
  • 2019 Capoccia, S. Marconi and C. De Lazzari. Review of Pressure-Volume Analysis. In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds.  New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 23-76.
  • 2019 De Lazzari, S. Marconi and M. Capoccia. Physiology of Ventricular Interdependence. In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds.  New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 77-118.
  • 2019 Marconi, M. Capoccia and C. De Lazzari. Mathematical Modelling of the Cardiovascular System In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds.  New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 119-158.
  • 2019 De Lazzari, S. Marconi and M. Capoccia. Interactions Between VADs and the Cardiovascular System. In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds.  New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 159-196.
  • 2019 Capoccia, S. Marconi and C. De Lazzari. Mathematical Modelling of Mechanical Circulatory Support. In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds. New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 261-298.
  • 2019 De Lazzari, S. Saltarocchi, I. Genuini and M. Capoccia. Clinical Applications. In: CONCEPTS, MATHEMATICAL MODELLING and APPLICATIONS in HEART FAILURE.  Massimo Capoccia and Claudio De Lazzari Eds.  New York:  Nova Science Publisher. (ISBN: 978-1-53614-771-1), 337-366.
  • 2017 De Lazzari, M. Pirckhalava Eds (2017). Book: CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2).
  • 2017 De Lazzari, M. Pirckhalava. “Medical Simulators for E-Learning and Teaching in Healthcare”, in CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. C. De Lazzari, M. Pirckhalava Eds. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2), 1-15.
  • 2017 De Lazzari, B. Quatember, K. Mottaghy, C. De Lazzari. “Numerical Models of the Cardiovascular System: Interaction Between the Septum and the Left (Right) Ventricular and Atrial Free Wall”, in CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. C. De Lazzari, M. Pirckhalava Eds. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2), 17-31.
  • 2017 De Lazzari, M. Capoccia. “In Silico Modelling of Right Continuous Flow Circulatory Support to Simulate RVAD Assistance”, in CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. C. De Lazzari, M. Pirckhalava Eds. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2), 65-86.
  • 2017 M. Bersani, E. Bersani, C. De Lazzari. “Interaction Between the Respiratory and Cardiovascular System: a Simplified 0-D Mathematical Model”, in CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. C. De Lazzari, M. Pirckhalava Eds. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2), 87-103.
  • 2017 De Lazzari, B. De Lazzari, I. Genuini M. Pirckhalava. “The Use of e-Learning for Healthcare Professionals: an Interactive in Silico Simulator”, in CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. C. De Lazzari, M. Pirckhalava Eds. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2), 161-181.
  • 2017 Cinque, F. Fedele, B. Quatember, I Genuini C. De Lazzari. “Interaction Between Mechanical Ventilation and Biventricular Pacemaker: Haemodynamic Studies Using Medical Simulation Software Platform”, in CARDIOVASCULAR and PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. C. De Lazzari, M. Pirckhalava Eds. Published by Consiglio Nazionale delle Ricerche (CNR) ROMA (ISBN 978-88-8080-240-2), 183-201.