Fisiologia cardiovascolare (P. Pagliaro)

Unità di Ricerca: Fisiologia (Pagliaro- Penna-Roatta)

Responsabile/Coordinatore: Prof. Claudia Penna
Delegato del Rettore: Prof Pasquale Pagliaro

Sede Universitaria Università degli Studi Torino, Dipartimento di Scienze Cliniche e Biologiche
Dipartimenti di Scienze Cliniche e Biologiche e Neuroscienze
Indirizzo: Regione Gonzole , 10- Orbassano (TO) 10043

tel: 011/6705470/5450

e-mail: claudia.penna@unito.it; pasquale.pagliaro@unito.it

sito web: https://www.dscb.unito.it/do/gruppi.pl/Show?_id=f5bx

Linee di ricerca:

Meccanismi e vie intracellulari di cardio-protezione in modelli dismetabolici. Meccanismo d’azione di mediatori peptidici con effetti cardioprotettivi. Biomateriali e cardiorigenerazione.

Meccanismi di controllo della perfusione muscolare e vaso-reattività alla stimolazione pneumatica.

Laboratori/strumentazione:

Lab. Di Fisiologia cellulare e cardiaca Sistema di perfusione per cuori isolati (ratti e topi)
Attrezzatura per l’isolamento di cellule cardiache e cellule staminali mesenchimali in condizioni di sterilità
Mantenimento in coltura di cellule cardiache e cellule staminali mesenchimali.
Camera Ipossica per colture cellulari e piccoli animali
Microscopio confocale e confocale invertito (Olympus fluoview)
Microscopio elettronico
ChemiDoc Touch
Lab Fisiologia Integrativa Amplificatore optoisolato 8 ch (EEG, ECG, EMG,…)
Sistema di acquisizione 16 ch CED 1401micro
Pedana stabilometrica
Near infrared spectroscopy (in prestito)
Flussimetro cutaneo laser-Doppler
Ecografo ESAOTE Mylab 25Gold
Sistema custom di compressione pneumatica degli arti

Collaborazioni internazionali:

Claudia Montero-Menei, University of Angers, Francia

Marisol Ruiz Meana, Cardiovascular Diseases Research Group, Vall d’Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d’Hebron, 08035 Barcelona, Spain.

Rainer Schulz, Institute of Physiology, Justus-Liebig-Universität, 35392 Giessen, Germany

Ioanna Andreadou, Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.

Stefano Toldo, Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, United States of America.

Nazareno Paolocci Johns Hopkins University, Baltimore, USA

Elenco ultime pubblicazioni:

  1. Allois R, Pagliaro P, Roatta S. Ischemic Conditioning to Reduce Fatigue in Isometric Skeletal Muscle Contraction. Biology (Basel). 2023;12:460.
  2. Rashid A, Santarcangelo EL, Roatta S. Cerebral Blood Flow in Healthy Subjects with Different Hypnotizability Scores. Brain Sci. 2022;12:558.
  3. Ermini L, Seddone S, Policastro P, Mesin L, Pasquero P, Roatta S. The Cardiac Caval Index: Improving Noninvasive Assessment of Cardiac Preload. J Ultrasound Med. 2022;41:2247-2258.
  4. Uberti F, Trotta F, Cavalli R, Galla R, Caldera F, Ferrari S, Mulè S, Brovero A, Molinari C, Pagliaro P, Penna C. Enhancing Vitamin D3 Efficacy: Insights from Complexation with Cyclodextrin Nanosponges and Its Impact on Gut-Brain Axes in Physiology and IBS Syndrome. Int J Mol Sci. 2024;25:2189.
  5. Angelone T, Rocca C, Lionetti V, Penna C, Pagliaro P. Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology. Antioxid Redox Signal. 2024. doi: 10.1089/ars.2023.0285.
  6. Pagliaro P, Penna C. Inhibitors of NLRP3 Inflammasome in Ischemic Heart Disease: Focus on Functional and Redox Aspects. Antioxidants (Basel). 2023;12:1396.
  7. Tannous M, Hoti G, Trotta F, Cavalli R, Higashiyama T, Pagliaro P, Penna C. Oxygen Nanocarriers for Improving Cardioplegic Solution Performance: Physico-Chemical Characterization. Int J Mol Sci. 2023;24:10073.
  8. Gastaldi S, Rocca C, Gianquinto E, Granieri MC, Boscaro V, Blua F, Rolando B, Marini E, Gallicchio M, De Bartolo A, Romeo N, Mazza R, Fedele F, Pagliaro P, Penna C, Spyrakis F, Bertinaria M, Angelone T. Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation. Eur J Med Chem. 2023;257:115542.
  9. Russo I, Barale C, Melchionda E, Penna C, Pagliaro P. Platelets and Cardioprotection: The Role of Nitric Oxide and Carbon Oxide. Int J Mol Sci. 2023;24:6107.
  10. Uberti F, Trotta F, Pagliaro P, Bisericaru DM, Cavalli R, Ferrari S, Penna C, Matencio A. Developing New Cyclodextrin-Based Nanosponges Complexes to Improve Vitamin D Absorption in an In Vitro Study. Int J Mol Sci. 2023;24:5322.
  11. Alloatti G, Penna C, Comità S, Tullio F, Aragno M, Biasi F, Pagliaro P. Aging, sex and NLRP3 inflammasome in cardiac ischaemic disease. Vascul Pharmacol. 2022;145:107001.
  12. Mancardi D, Ottolenghi S, Attanasio U, Tocchetti CG, Paroni R, Pagliaro P, Samaja M. Janus, or the Inevitable Battle Between Too Much and Too Little Oxygen. Antioxid Redox Signal. 2022;37:972-989.
  13. Penna C, Sorge M, Tullio F, Comità S, Femminò S, Brancaccio M, Pagliaro P. A TRICk to Improve the Effectiveness of RIC: Role of Limb Temperature in Enhancing the Effectiveness of Remote Ischemic Conditioning. Biology (Basel). 2022;11:146.
  14. Mancardi D, Pagliaro P, Ridnour LA, Tocchetti CG, Miranda K, Juhaszova M, Sollott SJ, Wink DA, Paolocci N. HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation. Antioxidants (Basel). 2022;11:382.
  15. Paterna M, Dvir Z, De Benedictis C, Maffiodo D, Franco W, Ferraresi C, Roatta S. Center of pressure displacement due to graded controlled perturbations to the trunk in standing subjects: the force-impulse paradigm. Eur J Appl Physiol. 2022;122:425-435.
  16. Severino P, D’Amato A, Prosperi S, Dei Cas A, Mattioli AV, Cevese A, Novo G, Prat M, Pedrinelli R, Raddino R, Gallina S, Schena F, Poggesi C, Pagliaro P, Mancone M, Fedele F, On Behalf Of The Italian National Institute For Cardiovascular Research Inrc. Do the Current Guidelines for Heart Failure Diagnosis and Treatment Fit with Clinical Complexity? J Clin Med. 2022;11:857.
  17. Albani S, Mesin L, Roatta S, De Luca A, Giannoni A, Stolfo D, Biava L, Bonino C, Contu L, Pelloni E, Attena E, Russo V, Antonini-Canterin F, Pugliese NR, Gallone G, De Ferrari GM, Sinagra G, Scacciatella P. Inferior Vena Cava Edge Tracking Echocardiography: A Promising Tool with Applications in Multiple Clinical Settings. Diagnostics (Basel). 2022;12:427.
  18. Rashid A, Santarcangelo EL, Roatta S. Cerebrovascular reactivity during visual stimulation: Does hypnotizability matter? Brain Res. 2022;1794:148059.
  19. Seddone S, Ermini L, Policastro P, Mesin L, Roatta S. Evidence that large vessels do affect near infrared spectroscopy. Sci Rep. 2022;12:2155.
  20. Femminò S, D’Ascenzo F, Ravera F, Comità S, Angelini F, Caccioppo A, Franchin L, Grosso A, Thairi C, Venturelli E, Cavallari C, Penna C, De Ferrari GM, Camussi G, Pagliaro P, Brizzi MF. Percutaneous Coronary Intervention (PCI) Reprograms Circulating Extracellular Vesicles from ACS Patients Impairing Their Cardio-Protective Properties. Int J Mol Sci. 2021;22:10270.
  21. D’Ascenzo F, Femminò S, Ravera F, Angelini F, Caccioppo A, Franchin L, Grosso A, Comità S, Cavallari C, Penna C, De Ferrari GM, Camussi G, Pagliaro P, Brizzi MF. Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury. Pharmacol Res. 2021;170:105715.
  22. Querio G, Geddo F, Antoniotti S, Gallo MP, Penna C. Sex and Response to Cardioprotective Conditioning Maneuvers. Front Physiol. 2021;12:667961.
  23. Penna C, Femminò S, Caldera F, Rubin Pedrazzo A, Cecone C, Alfì E, Comità S, Higashiyama T, Trotta F, Pagliaro P, Cavalli R. Cyclic Nigerosyl-Nigerose as Oxygen Nanocarrier to Protect Cellular Models from Hypoxia/Reoxygenation Injury: Implications from an In Vitro Model. Int J Mol Sci. 2021;22:4208.
  24. Carta G, Seregni A, Casamassima A, Galli M, Geuna S, Pagliaro P, Zago M. Validation and Reliability of a Novel Vagus Nerve Neurodynamic Test and Its Effects on Heart Rate in Healthy Subjects: Little Differences Between Sexes. Front Neurosci. 2021;15:698470.
  25. Penna C, Aragno M, Cento AS, Femminò S, Russo I, Bello FD, Chiazza F, Collotta D, Alves GF, Bertinaria M, Zicola E, Mercurio V, Medana C, Collino M, Pagliaro P. Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades. Oxid Med Cell Longev. 2020;2020:9219825.