Università di Parma – Sezione di Endocrinologia e Malattie del Metabolismo

Unità di Ricerca: Sezione di Endocrinologia e Malattie del Metabolismo

Dipartimento di Medicina e Chirurgia
Direttore Prof. RC Bonadonna

Responsabile/Coordinatore in seno al Consorzio

Prof. Alessandra Dei Cas
Sede Universitaria: Università di Parma
Dipartimento di Medicina e Chirurgia
Indirizzo: Via Gramsci, 14 43126 Parma

tel: 0521 033321

e-mail: alessandra.deicas@unipr.it

sito web: https://www.unipr.it/ugov/person/18004

Linee di ricerca:

Le principali linee di ricerca di cui mi sono occupata sono le seguenti:

  1. Basi molecolari e cellulari della nefropatia diabetica
  2. Patobiologia delle cellule derivate dai monociti: macrofagi e cellule mieloidi angiogeniche
  3. Farmaci anti-diabete: basi molecolari e cellulari della protezione d’organo

Laboratori/strumentazione:

I laboratori dell’Unità di Endocrinologia e malattie del metabolismo sono attrezzati con le principali strumentazioni di Biologia Cellulare e Molecolare: cappa sterile (Aerius), cappa, incubatore (Aerius), Centrifuga, Real Time PCR (BioRad), microscopio invertito (Nikon) spettrofotometro (Thermo Scientific) e, in particolare la tecnologia Agilent Seahorse® XF.

L’Unità di Endocrinologia e malattie del metabolismo inoltre dispone di una Trial Unit con personale dedicato.

Collaborazioni internazionali:

  1. Prof. Luigi Gnudi – Department of Diabetes, Endocrinology and Internal Medicine, Cardiovascular Division Guy’s, King’s and St. Thomas School of Medicine del King’s College di Londra (UK)
  2. Prof.ssa Miriam Cnop – Center for diabetes research of ULB Universitè Libre de Bruxelles (Bruxelles, Belgio).

Elenco pubblicazioni del triennio 2017 – 2019:

  1. Nasi M, Patrizi G, Pizzi C, Landolfo M, Boriani G, Dei Cas A, Cicero AFG, Fogacci F, Rapezzi C, Sisca G, Capucci A, Vitolo M, Galiè N, Borghi C, Berrettini U, Piepoli M, Mattioli AV. The role of physical activity in individuals with cardiovascular risk factors: an opinion paper from Italian Society of Cardiology-Emilia Romagna-Marche and SIC-Sport. J Cardiovasc Med (Hagerstown). 2019;20(10):631-639.
  2. Petroni ML, Barbanti FA, Bonadonna R, Bruno G, Caletti MT, Croci M, D’Eusebio C, Dei Cas A, Invitti C, Merlo F, Molteni A, Pontiroli A, Trento M, Veronelli A, Vigili de Kreutzenberg S, Marchesini G. Dysfunctional eating in type 2 diabetes mellitus: A multicenter Italian study of socio-demographic and clinical associations. Nutr Metab Cardiovasc Dis. 2019;29(9):983-990.
  3. Fadini GP, Li Volsi P, Devangelio E, Poli M, Cazzetta G, Felace G, Avogaro A; DARWIN-T2D Network. Predictors of early discontinuation of dapagliflozin versus other glucose-lowering medications: a retrospective multicenter real-world study. J Endocrinol Invest. 2019 Sep 12. doi: 10.1007/s40618
  4. Fadini GP, Sciannameo V, Franzetti I, Bottigliengo D, D’Angelo P, Vinci C, Berchialla P, Arena S, Buzzetti R, Avogaro A; DARWIN-T2D network. Similar effectiveness of dapagliflozin and GLP-1 receptor agonists concerning combined endpoints in routine clinical practice: A multicentre retrospective study. Diabetes Obes Metab. 2019 Aug;21(8):1886-1894
  5. Mattioli AV, Sciomer S, Moscucci F, Maiello M, Cugusi L, Gallina S, Dei Cas A, Lombardi C, Pengo M, Parati G, Barilla F, Ciccone MM, Palmiero P, Mercuro G, Maffei S. Cardiovascular prevention in women: a narrative review from the Italian Society of Cardiology working groups on ‘Cardiovascular Prevention, Hypertension and peripheral circulation’ and on ‘Women Disease’. J Cardiovasc Med (Hagerstown). 2019;20(9):575-583.
  6. Maack C, Lehrke M, Backs J, Heinzel FR, Hulot JS, Marx N, Paulus WJ, Rossignol P, Taegtmeyer H, Bauersachs J, Bayes-Genis A, Brutsaert D, Bugger H, Clarke K, Cosentino F, De Keulenaer G, Dei Cas A, González A, Huelsmann M, Iaccarino G, Lunde IG, Lyon AR, Pollesello P, Rena G, Riksen NP, Rosano G, Staels B, van Laake LW, Wanner C, Farmakis D, Filippatos G, Ruschitzka F, Seferovic P, de Boer RA, Heymans S. Eur Heart J. 2018;39(48):4243-4254. Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology. Eur Heart J. 2018;39(48):4243-4254. Cited 0; IF 23,425
  7. Mirijello A, Viazzi F, Fioretto P, Giorda C, Ceriello A, Russo GT, Guida P, Pontremoli R, De Cosmo S; AMD ANNALS Study Group. Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes. BMC Nephrol. 2018 Dec 4;19(1):347
  8. Fadini GP, Bottigliengo D, D’Angelo F, Cavalot F, Bossi AC, Zatti G, Baldi I, Avogaro A; DARWIN-T2D Network. Comparative Effectiveness of DPP-4 Inhibitors Versus Sulfonylurea for the Treatment of Type 2 Diabetes in Routine Clinical Practice: A Retrospective Multicenter Real-World Study. Diabetes Ther. 2018;9(4):1477-1490.
  9. Fadini GP, Solini A, Manca ML, Zatti G, Karamouzis I, Di Benedetto A, Frittitta L, Avogaro A; DARWIN-T2D Network. Phenotyping normal kidney function in elderly patients with type 2 diabetes: a cross-sectional multicentre study. Acta Diabetol. 2018;55(11):1121-1129.
  10. Martini D, Innocenti A, Cosentino C, Bedogni G, Angelino D, Biasini B, Zavaroni I, Ventura M, Galli D, Mirandola P, Vitale M, Dei Cas A, Bonadonna RC, Passeri G, Pruneti C, Del Rio D. Claimed Effects, Outcome Variables and Methods of Measurement for Health Claims on Foods Related to Vision Proposed Under Regulation (EC) 1924/2006. Nutrients. 2018;10(2). Cited 0; IF 3,55
  11. Martini D, Innocenti A, Cosentino C, Bedogni G, Zavaroni I, Ventura M, Galli D, Mirandola P, Vitale M, Dei Cas A, Bonadonna RC, Passeri G, Pruneti C, Del Rio D. Claimed effects, outcome variables and methods of measurement for health claims proposed under regulation (EC) 1924/2006 and related to cognitive function in adults. Arch Ital Biol. 2018;156(1-2):64-86. Cited 0; IF 0
  12. Martini D, Biasini B, Zavaroni I, Bedogni G, Musci M, Pruneti C, Passeri G, Ventura M, Galli D, Mirandola P, Vitale M, Dei Cas A, Bonadonna RC, Del Rio D. Claimed effects, outcome variables and methods of measurement for health claims proposed under European Community Regulation 1924/2006 in the area of blood glucose and insulin concentrations. Acta Diabetol. 2018;55(4):391-404. Cited 0; IF 3,34
  13. Biasini B, Marchi L, Angelino D, Bedogni G, Zavaroni I, Pruneti C, Galli D, Mirandola P, Vitale M, Dei Cas A, Bonadonna RC, Passeri G, Ventura M, Del Rio D, Martini D. Claimed effects, outcome variables and methods of measurement for health claims on foods related to the gastrointestinal tract proposed under regulation (EC) 1924/2006. Int J Food Sci Nutr. 2018:1-34. Cited 3; IF 1,444
  14. Lepore G, Bonfanti R, Bozzetto L, Di Blasi V, Girelli A, Grassi G, Iafusco D, Laviola L, Rabbone I, Schiaffini R, Bruttomesso D; Italian Study Group on the Diffusion of CSII. Metabolic control and complications in Italian people with diabetes treated with continuous subcutaneous insulin infusion. Nutr Metab Cardiovasc Dis. 2018;28(4):335-342.
  15. Martini D, Galli, C, Guareschi, C, Angelino D, Bedogni, G, Biasini B, Zavaroni I, Pruneti, C, Ventura M, Galli D, Mirandola P, Vitale M, Dei Cas A, Bonadonna R.C, Passeri G., Del Rio D. Claimed effects, outcome variables and methods of measurement for health claims on foods proposed under Regulation (EC) 1924/2006 in the area of oral health. NFS Journal 2018;10:10-25. Cited 2
  16. Martini D, Guareschi C, Biasini B, Bedogni, G, Galli C, Angelino D, Marchi L, Zavaroni I, Pruneti C, Ventura M, Galli, D, Mirandola P, Vitale, M, Dei Cas A, Bonadonna R.C., Passeri G, Del Rio D. Claimed effects, outcome variables and methods of measurement for health claims proposed under Regulation (EC) 1924/2006 in the framework of bone health. PharmaNutrition 2018; 6(1):17-36. Cited 2.
  17. Martini D, Angelino D, Cortelazzi C, Zavaroni I, Bedogni G, Musci M, Pruneti C, Passeri G, Ventura M, Galli D, Mirandola P, Vitale M, Dei Cas A, Bonadonna RC, Di Nuzzo S, De Felici MB, Del Rio D. Claimed Effects, Outcome Variables and Methods of Measurement for Health Claims Proposed Under European Community Regulation 1924/2006 in the Framework of Maintenance of Skin Function. 2017;10(1). Cited 3; IF 3,55
  18. Spigoni V, Mena P, Fantuzzi F, Tassotti M, Brighenti F, Bonadonna RC, Del Rio D, Dei Cas A. Bioavailability of Bergamot (Citrus bergamia) Flavanones and Biological Activity of Their Circulating Metabolites in Human Pro-Angiogenic Cells. Nutrients. 2017;9(12). Cited 1; IF 3,55
  19. Fadini GP, Zatti G, Consoli A, Bonora E, Sesti G, Avogaro A; DARWIN-T2D Network. Rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes): A multicenter retrospective nationwide Italian study and crowdsourcing opportunity. Nutr Metab Cardiovasc Dis. 2017;27(12):1089-1097. Cited 6
  20. Martini D, Biasini B, Rossi S, Zavaroni I, Bedogni G, Musci M, Pruneti C, Passeri G, Ventura M, Galli D, Mirandola P, Vitale M, Dei Cas A, Bonadonna RC, Del Rio D. Claimed effects, outcome variables and methods of measurement for health claims on foods proposed under European Community Regulation 1924/2006 in the area of appetite ratings and weight management. Int J Food Sci Nutr. 2017;28:1-21. Cited 5; IF 1,444
  21. Mattioli AV, Palmiero P, Manfrini O, Puddu PE, Nodari S, Dei Cas A, Mercuro G, Scrutinio D, Palermo P, Sciomer S, Di Francesco S, Novo G, Novo S, Pedretti RFE, Zito A, Parati G, Pedrinelli R, Farinetti A, Maiello M, Moscucci F, Tenaglia RL, Sucato V, Triggiani M, Cugusi L, Scicchitano P, Saba PS, Ciccone MM. Mediterranean diet impact on cardiovascular diseases: a narrative review. J Cardiovasc Med (Hagerstown). 2017;18(12):925-935. Cited 14; IF 1,613
  22. Spigoni V, Fantuzzi F, Fontana A, Cito M, Derlindati E, Zavaroni I, Cnop M, Bonadonna RC, Dei Cas A. Stearic acid at physiologic concentrations induces in vitro lipotoxicity in circulating angiogenic cells. 2017;265:162-171. Cited 1. IF 4,239.
  23. Pasin F, Caroli B, Spigoni V, Dei Cas A, Volpi R, Galli C, Passeri G. Performance and antrhropometric characteristics of Elite Rugby Players. Acta Biomed. 2017;88(2):172-177.Cited 1, IF=0.
  24. Matone A, Derlindati E, Marchetti L, Spigoni V, Dei Cas A, Montanini B, Ardigò D, Zavaroni I, Priami C, Bonadonna RC. Identification of an early transcriptomic signature of insulin resistance and related diseases in lymphomonocytes of healthy subjects. PLoS One. 2017;12(8):e0182559. Cited 1; IF 2,806
  25. Spigoni V, Aldigeri R, Antonini M, Micheli MM, Fantuzzi F, Fratter A, Pellizzato M, Derlindati E, Zavaroni I, Bonadonna RC, Dei Cas A. Effects of a New Nutraceutical Formulation (Berberine, Red Yeast Rice and Chitosan) on Non-HDL Cholesterol Levels in Individuals with Dyslipidemia: Results from a Randomized, Double Blind, Placebo-Controlled Study. Int J Mol Sci. 2017;18(7). Cited 4; IF 3,266.
  26. Martini D, Rossi S, Biasini B, Zavaroni I, Bedogni G, Musci M, Pruneti C, Passeri G, Ventura M, Di Nuzzo S, Galli D, Mirandola P, Vitale M, Dei Cas A, Bonadonna RC, Del Rio D. Claimed effects, outcome variables and methods of measurement for health claims proposed under European Community Regulation 1924/2006 in the framework of protection against oxidative damage and cardiovascular health. Nutr Metab Cardiovasc Dis. 2017;27(6):473-503. Cited 9; IF 3,679.
  27. Scazzina F, Dei Cas A, Del Rio D, Brighenti F, Bonadonna RC. The β-cell burden index of food: A proposal. Nutr Metab Cardiovasc Dis. 2016;26(10):872-878. Cited 1; IF 3,679.
  28. Dei Cas A, Spigoni V, Cito M, Aldigeri R, Ridolfi V, Marchesi E, Marina M, Derlindati E, Aloe R, Bonadonna RC, Zavaroni I. Vildagliptin, but not glibenclamide, increases circulating endothelial progenitor cell number: a 12-month randomized controlled trial in patients with type 2 diabetes. Cardiovasc Diabetol. 2017;16(1):27. Cited 10; IF 4,752.