Medicina Traslazionale Nefro-Vascolare – Bologna

Unità di Ricerca: Medicina Traslazionale Nefro-Vascolare
Coordinatore: Prof. Gianandrea Pasquinelli
Sede Universitaria: Università di Bologna, Dipartimento di Medicina Specialistica Diagnostica e Sperimentale, Sezione di Scienze Tecniche di Laboratorio

 

Indirizzo: Policlinico S. Orsola, Padiglione 11, via Massarenti 9, 40138, Bologna

tel: 051 2144288
fax:
e-mail: gianandr.pasquinelli@unibo.it

sito web:
Linee di ricerca:

– Ottimizzazione del trapianto renale mediante derivati da cellule staminali umane

– Ruolo delle cellule staminali umane nei processi di calcificazione arteriosa

 

Laboratori/strumentazione:

LABORATORI STRUMENTAZIONE
Patologia Clinica (utilizzo prevalente) e Anatomia Patologica Strumentazione di base per allestimento di colture cellulari, western blot, PCR; allestimento di preparati istologici, di immunofluorescenza e di immunoistochimica; microscopia elettronica a trasmissione e a scansione; microscopia confocale
 

 

Collaborazioni internazionali:

 

Prof. W. Thilly e Dr. E. Gostijeva del Dept. of Biological Engineering, Massachusetts Institute of Technology – MIT, Boston, USA (2010-tutt’oggi).

 

Elenco pubblicazioni del triennio 2016 – 2018:

 

  1. Ravaioli M, Baldassare M, Vasuri F, Pasquinelli G, Laggetta M, Valente S, De Pace V, Neri F, Siniscalchi A, Zanfi C, Bertuzzo VR, Caraceni P, Trerè D, Longobardi P, Pinna AD. Strategies to Restore Adenosine Triphosphate (ATP) Level After More than 20 Hours of Cold Ischemia Time in Human Marginal Kidney Grafts. Ann Transplant. 2018 Jan 12;23:34-44. PubMed PMID: 29326416.

 

  1. Bisceglia M, Muscarella LA, Galliani CA, Zidar N, Ben-Dor D, Pasquinelli G, la Torre A, Sparaneo A, Fanburg-Smith JC, Lamovec J, Michal M, Bacchi CE. Extraneuraxial Hemangioblastoma: Clinicopathologic Features and Review of the Literature. Adv Anat Pathol. 2017 Nov 20. doi: 10.1097/PAP.0000000000000176. [Epub ahead of print] PubMed PMID: 29189208.

 

  1. Zazzeroni L, Pasquinelli G, Nanni E, Cremonini V, Rubbi I. Comparison of Quality of Life in Patients Undergoing Hemodialysis and Peritoneal Dialysis: a Systematic Review and Meta-Analysis. Kidney Blood Press Res. 2017 Oct 19;42(4):717-727. doi: 10.1159/000484115. [Epub ahead of print] PubMed PMID: 29049991.

 

  1. Donati M, Cenacchi G, Biondi R, Papa V, Borel N, Nepita EV, Magnino S, Pasquinelli G, Levi A, Franco OL. Activity of synthetic peptides against Chlamydia. Biopolymers. 2017 May 27. doi: 10.1002/bip.23032. [Epub ahead of print] PubMed PMID: 28555934.

 

  1. Pasquinelli G, Thilly WG, Gostjeva EV, Todeschini P, Cianciolo G, Ronco C, La Manna G. Restenosis in Hemodialytic Fistulas and Chronic Kidney Disease-Associated Vascular Disease: Two Pathologies Driven by Metakaryotic Stem Cells. Contrib Nephrol. 2017;190:96-107. doi: 10.1159/000468954. Epub 2017 May 23. PubMed PMID: 28535522.

 

  1. Pini R, Faggioli G, Fittipaldi S, Vasuri F, Longhi M, Gallitto E, Pasquinelli G, Gargiulo M, Stella A. Relationship between Calcification and Vulnerability of the Carotid Plaques. Ann Vasc Surg. 2017 Oct;44:336-342. doi:10.1016/j.avsg.2017.04.017. Epub 2017 May 4. PubMed PMID: 28479433.

 

  1. Ciavarella C, Gallitto E, Ricci F, Buzzi M, Stella A, Pasquinelli G. The crosstalk between vascular MSCs and inflammatory mediators determines the pro-calcific remodelling of human atherosclerotic aneurysm. Stem Cell Res Ther. 2017 Apr 26;8(1):99. doi: 10.1186/s13287-017-0554-x. PubMed PMID: 28446225; PubMed Central PMCID: PMC5406974.

 

  1. Cimini M, Cannatá A, Pasquinelli G, Rota M, Goichberg P. Phenotypically heterogeneous podoplanin-expressing cell populations are associated with the lymphatic vessel growth and fibrogenic responses in the acutely and chronically infarcted myocardium. PLoS One. 2017 Mar 23;12(3):e0173927. doi: 10.1371/journal.pone.0173927. eCollection 2017. PubMed PMID: 28333941; PubMed Central PMCID: PMC5363820.

 

  1. Fittipaldi S, Pini R, Pasquinelli G, Mauro R, Beltrandi E, Freyrie A, Gargiulo M, Faggioli G, Stella A. High sensitivity C-reactive protein and vascular endothelial growth factor as indicators of carotid plaque vulnerability. J Cardiovasc Surg (Torino). 2016 Dec;57(6):861-871. Epub 2014 Mar 19. PubMed PMID: 24647324.

 

  1. Fabbri R, Macciocca M, Vicenti R, Pasquinelli G, Caprara G, Valente S, Seracchioli R, Paradisi R. Long-term storage does not impact the quality of cryopreserved human ovarian tissue. J Ovarian Res. 2016 Aug 24;9(1):50. doi: 10.1186/s13048-016-0261-8. PubMed PMID: 27557782; PubMed Central PMCID: PMC4995754.

 

  1. Fittipaldi S, Vasuri F, Degiovanni A, Pini R, Gargiulo M, Stella A, Pasquinelli G, Thilly WG, Gostjeva EV. The study of calcified atherosclerotic arteries: an alternative to evaluate the composition of a problematic tissue reveals new insight including metakaryotic cells. BMC Clin Pathol. 2016 Jul 29;16:12. doi: 10.1186/s12907-016-0036-6. eCollection 2016. PubMed PMID: 27478409; PubMed Central PMCID: PMC4966787.

 

  1. Fabbri R, Vicenti R, Macciocca M, Martino NA, Dell’Aquila ME, Pasquinelli G, Morselli-Labate AM, Seracchioli R, Paradisi R. Morphological, ultrastructural and functional imaging of frozen/thawed and vitrified/warmed human ovarian tissue retrieved from oncological patients. Hum Reprod. 2016 Aug;31(8):1838-49. doi: 10.1093/humrep/dew134. Epub 2016 Jun 9. PubMed PMID: 27282911.

 

  1. Fabbri R, Macciocca M, Vicenti R, Paradisi R, Klinger FG, Pasquinelli G, Spisni E, Seracchioli R, Papi A. Doxorubicin and cisplatin induce apoptosis in ovarian stromal cells obtained from cryopreserved human ovarian tissue. Future Oncol. 2016 Jul;12(14):1699-711. doi: 10.2217/fon-2016-0032. Epub 2016 May 13. PubMed PMID: 27173589.

 

  1. Ciavarella C, Fittipaldi S, Pasquinelli G. CoCl2 Administration to Vascular MSC Cultures as an In Vitro Hypoxic System to Study Stem Cell Survival and Angiogenesis. Methods Mol Biol. 2016;1516:309-317. doi: 10.1007/7651_2016_350. PubMed PMID: 27052613.

 

  1. Vasuri F, Freyrie A, Pasquinelli G. Unusual lamellar calcifications in two rare cases of splenic aneurysms associated with fibromuscular dysplasia. Ultrastruct Pathol. 2016;40(2):116-20. doi: 10.3109/01913123.2016.1156797. PubMed PMID: 27031177.

 

  1. Valente S, Ciavarella C, Pasanisi E, Ricci F, Stella A, Pasquinelli G. Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing. Stem Cells Int. 2016;2016:3232859. doi: 10.1155/2016/3232859. Epub 2015 Dec 14. PubMed PMID: 26788066; PubMed Central PMCID: PMC4691635.

 

  1. Vasuri F, Fittipaldi S, Pacilli A, Buzzi M, Pasquinelli G. The incidence and morphology of Monckeberg’s medial calcification in banked vascular segments from a monocentric donor population. Cell Tissue Bank. 2016 Jun;17(2):219-23. doi:10.1007/s10561-016-9543-z. Epub 2016 Jan 12. PubMed PMID: 26757897.

 

  1. Vasuri F, Fittipaldi S, Giunchi F, Monica M, Ravaioli M, Degiovanni A, Bonora S, Golfieri R, Bolondi L, Grigioni WF, Pasquinelli G, D’Errico-Grigioni A. Facing the enigma of the vascular network in hepatocellular carcinomas in cirrhotic and non-cirrhotic livers. J Clin Pathol. 2016 Feb;69(2):102-8. doi: 10.1136/jclinpath-2015-203028. Epub 2015 Aug 4. PubMed PMID: 26243063.