Unità di Ricerca: Immunologia cellulare e molecolare nelle malattie cardiovascolari
Responsabile/Coordinatore: Prof. Marcello Pinti
Università di Modena e Reggio Emilia
Dipartimento di Scienze della vita.
Via Giuseppe Campi 287, 41125 Modena (MO)
tel: 059 205.5386
e-mail: marcello.pinti@unimore.it
sito web: https://www.dsv.unimore.it/site/home/ricerca/gruppo-di-ricerca.html?id=214
Componenti:
Prof. Milena Nasi
Dr. Giada Zanini
Dr. Valentina Selleri
Dr. Giorgia Sinigaglia
Dr. Giulia Micheloni
Dr. Mara Malerba
Linee di ricerca: 1. Ruolo del DNA mitocondriale circolante (mtDNA) come molecola proinfiammatoria. Il mtDNA, quando rilasciato all’esterno delle cellule, può agire come pattern molecolare associato al danno e innescare una reazione infiammatoria. Il nostro gruppo analizza il contributo del’mtDNA all’infiammazione durante il processo aterosclerotico, e nell’invecchiamento fisiologico. 2. Identificazione e di nuovi biomarcatori associati alle malattie cardiovascolari in una prospettiva di genere, e messa a punto di dispositivi ad alta sensibilità per il monitoraggio di tali marcatori. 3. Caratterizzazione della funzionalità mitocondriale nella risposta immunitaria associata all’invecchiamento.
Laboratori/strumentazione: Centrifughe e ultracentrifughe, strumentazione di base per biologia cellulare e molecolare, Real time PCR, ddPCR, Termociclatore, Cappa a flusso laminare, Incubatore CO2, Frigoriferi, Congelatori -20°C e -80°C. Accesso a laboratorio di colture cellulari certificato, Centro grandi strumenti.
Collaborazioni internazionali: Dipartimento di Farmacologia, Università di Valencia (Valencia, Spagna); Facoltà di Medicina e scienza, Università San Sebastian (Santiago del Cile, Cile), Linkoping University (Linkoping, Svezia).
Elenco ultime pubblicazioni: 1. Zanini G, Selleri V, Roncati L, Coppi F, Nasi M, Farinetti A, et al. Vascular “Long COVID”: A New Vessel Disease? Angiology. 2024;75(1):8-14.
2. Zanini G, Selleri V, Roncati L, Coppi F, Nasi M, Farinetti A, et al. Reply to: Letter on the Recent Paper “Vascular ‘Long COVID’: A New Vessel Disease?”. Angiology. 2024;75(1):99-100.
3. Zanini G, Selleri V, Malerba M, Solodka K, Sinigaglia G, Nasi M, et al. The Role of Lonp1 on Mitochondrial Functions during Cardiovascular and Muscular Diseases. Antioxidants (Basel). 2023;12(3).
4. Zanini G, Selleri V, Lopez Domenech S, Malerba M, Nasi M, Mattioli AV, et al. Mitochondrial DNA as inflammatory DAMP: a warning of an aging immune system? Biochem Soc Trans. 2023;51(2):735-45.
5. Sensi M, de Oliveira RF, Berto M, Palmieri M, Ruini E, Livio PA, et al. Reduced Graphene Oxide Electrolyte-Gated Transistor Immunosensor with Highly Selective Multiparametric Detection of Anti-Drug Antibodies. Adv Mater. 2023;35(36):e2211352.
6. Pinti M, Gibellini L, Lo Tartaro D, De Biasi S, Nasi M, Borella R, et al. A Comprehensive Analysis of Cytokine Network in Centenarians. Int J Mol Sci. 2023;24(3).
7. Mattioli AV, Moscucci F, Sciomer S, Maffei S, Nasi M, Pinti M, et al. Cardiovascular prevention in women: an update by the Italian Society of Cardiology working group on ‘Prevention, hypertension and peripheral disease’. J Cardiovasc Med (Hagerstown). 2023;24(Suppl 2):e147-e55.
8. Mattioli AV, Coppi F, Nasi M, Pinti M, Gallina S. Long COVID: A New Challenge for Prevention of Obesity in Women. Am J Lifestyle Med. 2023;17(1):164-8.
9. Martinelli I, Zucchi E, Simonini C, Gianferrari G, Zamboni G, Pinti M, et al. The landscape of cognitive impairment in superoxide dismutase 1-amyotrophic lateral sclerosis. Neural Regen Res. 2023;18(7):1427-33.
10. Martinelli I, Ghezzi A, Zucchi E, Gianferrari G, Ferri L, Moglia C, et al. Predictors for progression in amyotrophic lateral sclerosis associated to SOD1 mutation: insight from two population-based registries. J Neurol. 2023;270(12):6081-92.
11. Mandrioli J, D’Amico R, Zucchi E, De Biasi S, Banchelli F, Martinelli I, et al. Randomized, double-blind, placebo-controlled trial of rapamycin in amyotrophic lateral sclerosis. Nat Commun. 2023;14(1):4970.
12. Coppi F, Bucciarelli V, Sinigaglia G, Zanini G, Selleri V, Nasi M, et al. Sex Related Differences in the Complex Relationship between Coffee, Caffeine and Atrial Fibrillation. Nutrients. 2023;15(15).
13. Zanini G, Selleri V, Nasi M, De Gaetano A, Martinelli I, Gianferrari G, et al. Mitochondrial and Endoplasmic Reticulum Alterations in a Case of Amyotrophic Lateral Sclerosis Caused by TDP-43 A382T Mutation. Int J Mol Sci. 2022;23(19).
14. Zanini G, Selleri V, De Gaetano A, Gibellini L, Malerba M, Mattioli AV, et al. Differential Expression of Lonp1 Isoforms in Cancer Cells. Cells. 2022;11(23).
15. Selleri V, Mattioli M, Lo Tartaro D, Paolini A, Zanini G, De Gaetano A, et al. Innate immunity changes in soccer players after whole-body cryotherapy. BMC Sports Sci Med Rehabil. 2022;14(1):185.
16. Nasi M, De Gaetano A, Carnevale G, Bertoni L, Selleri V, Zanini G, et al. Effects of Energy Drink Acute Assumption in Gastrointestinal Tract of Rats. Nutrients. 2022;14(9).
17. Mattioli AV, Selleri V, Zanini G, Nasi M, Pinti M, Stefanelli C, et al. Physical Activity and Diet in Older Women: A Narrative Review. J Clin Med. 2022;12(1).
18. Mattioli AV, Nasi M, Pinti M, Palumbo C. Teaching Gender Differences at Medical School Could Improve the Safety and Efficacy of Personalized Physical Activity Prescription. Front Cardiovasc Med. 2022;9:919257.
19. Lo Tartaro D, Camiro-Zuniga A, Nasi M, De Biasi S, Najera-Avila MA, Jaramillo-Jante MDR, et al. Effective Treatment of Patients Experiencing Primary, Acute HIV Infection Decreases Exhausted/Activated CD4+ T Cells and CD8+ T Memory Stem Cells. Cells. 2022;11(15).
20. Gibellini L, Borella R, De Gaetano A, Zanini G, Tartaro DL, Carnevale G, et al. Evidence for mitochondrial Lonp1 expression in the nucleus. Sci Rep. 2022;12(1):10877.
21. Coppi F, Pinti M, Selleri V, Zanini G, D’Alisera R, Latessa PM, et al. Cardiovascular Effects of Whole-Body Cryotherapy in Non-professional Athletes. Front Cardiovasc Med. 2022;9:905790.
22. Zanini G, De Gaetano A, Selleri V, Savino G, Cossarizza A, Pinti M, et al. Mitochondrial DNA and Exercise: Implications for Health and Injuries in Sports. Cells. 2021;10(10).
23. Sensi M, Berto M, Gentile S, Pinti M, Conti A, Pellacani G, et al. Anti-drug antibody detection with label-free electrolyte-gated organic field-effect transistors. Chem Commun (Camb). 2021;57(3):367-70.
24. Mazaheri-Tehrani E, Mohraz M, Nasi M, Chester J, De Gaetano A, Lo Tartaro D, et al. NLRP3 and IL-1beta Gene Expression Is Elevated in Monocytes From HIV-Treated Patients With Neurocognitive Disorders. J Acquir Immune Defic Syndr. 2021;86(4):496-9.
25. Mattioli AV, Coppi F, Nasi M, Pinti M. Letter: Does Obesity Affect the Severity of Exercise-Induced Muscle Injury? (J Obes Metab Syndr 2021;30:132-40). J Obes Metab Syndr. 2021;30(3):312-4.
26. De Gaetano A, Solodka K, Zanini G, Selleri V, Mattioli AV, Nasi M, et al. Molecular Mechanisms of mtDNA-Mediated Inflammation. Cells. 2021;10(11).
27. De Gaetano A, Gibellini L, Zanini G, Nasi M, Cossarizza A, Pinti M. Mitophagy and Oxidative Stress: The Role of Aging. Antioxidants (Basel). 2021;10(5).
28. De Biasi S, Gibellini L, Lo Tartaro D, Puccio S, Rabacchi C, Mazza EMC, et al. Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy. Nat Commun. 2021;12(1):1669.
29. Cossarizza A, Chang HD, Radbruch A, Abrignani S, Addo R, Akdis M, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition). Eur J Immunol. 2021;51(12):2708-3145.
30. Burtscher B, Manco Urbina PA, Diacci C, Borghi S, Pinti M, Cossarizza A, et al. Sensing Inflammation Biomarkers with Electrolyte-Gated Organic Electronic Transistors. Adv Healthc Mater. 2021;10(20):e2100955.
31. Nasi M, Bianchini E, Lo Tartaro D, De Biasi S, Mattioli M, Paolini A, et al. Effects of whole-body cryotherapy on the innate and adaptive immune response in cyclists and runners. Immunol Res. 2020;68(6):422-35.